PGD directions in AVA-Peter
PGD is implemented in our practice in the following directions:
- unbalanced chromosome set in embryos of translocation carriers
- common aneuploidies (chromosomes 13, 16, 18, 22, 23, X, Y)
- detection of the embryo"s genetic sex – sex selection
Aneuploidies.
Under aneuploidy we understand abnormal number in one or several chromosomes.
Diagnostic of the common aneuploidies is indicated to all the women above 35, undergoing IVF. At this age the proportion of oocytes with lacking or excessive chromosomes considerably increases. Chromosomes 13, 16, 18, 21, 22, X, Y "participate" in aneuploidies most often. For example, Down syndrome is an example of aneuploidy – chromosome 21 is represented not by two copies as all the other chromosomes, but by three.
Aneuploidy in other above mentioned chromosomes may lead to implantation failure or pregnancy loss. Hence PGD for common aneuploidies is recommended in the case of three or more miscarriages in early pregnancy in previous history, as well as after three or more unsuccessful IVF attempts.
PGD for aneuploidies is aimed at increasing the conception rate and reducing the risk of miscarriage.
Translocations.
PGD for translocations is recommended to couples if one of the partners is a translocation carrier. The objective of the PGD for translocation is to increase the conception rate and reduce the risk of miscarriage, choosing for the transfer an embryo(s) with balanced chromosomal set.
Sex selection.
PGD can detect child's sex, thereby helping to avoid sex-linked genetic disease in an offspring, if one of the parents is a carrier. Sex selection may be performed also for family balancing (if, for example, a couple already has a boy and would like to have a girl).
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